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The Four Mountains
Test (VR).

Client Conduct Science
Affiliation Harvard Med / MGH

We partnered with Dr. Shuhan He (Massachusetts General Hospital / Harvard Medical School) and Conduct Science to develop the VR adaptation of the "Four Mountains Test"—a gold-standard tool for spatial memory assessment and Alzheimer's research.

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CLIENT: CONDUCT SCIENCE LABS: 2,400+ WORLDWIDE

2.4k+

Labs Served

HMS

Harvard Medical

L

Shaped Route

AI

Neuro Analysis

A Diagnostic Tool for the Mind.

The Four Mountains Test was originally used to assess a person’s ability to recognize and recreate spatial layouts. In our VR version, participants are immersed in a virtual environment where they must walk a guided path and navigate back to the start from memory.

Research indicates that poor performance on this test correlates with declining Entorhinal Cortex volume, making it a valuable biomarker for early molecular neurodegeneration in Alzheimer's disease.

Metric: Absolute Distance Error (m) Region: Hippocampus / Entorhinal Stimuli: Allocentric Spatial Cues Status: Clinical Research Tool

How It Works

An immersive setup providing a more dynamic evaluation than traditional paper tests.

1. Guided 'L' Route

The participant follows a guided ‘L’-shaped path to visit three distinct locations marked by inverted cones, experiencing different visual cues.

2. Spatial Recall

At the final location, the markers disappear. The participant must harness their spatial memory to navigate back to the exact starting coordinates.

3. Data Analysis

We compute the "Absolute Distance Error." Higher error rates can signal cognitive impairment linked to early-stage dementia.

Paper vs. VR

Traditional tests involved recognizing photos on paper. VR allows for controlled variations and machine learning analysis of movement patterns.

Shuhan He, MD

Founder, Conduct Science
Assistant Professor, Harvard Medical School
Emergency Medicine Physician, MGH

"Conduct Science supplies novel research platforms to more than 2,400 laboratories worldwide. We partnered with TopCode to digitize the Four Mountains Test, making it accessible to a global network of neuroscientists."

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